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Subcutaneously Administered Tirzepatide Vs Semaglutide for Adults With Type 2 Diabetes: A Systematic Review and Network Meta-analysis of Randomised Controlled Trials
This phenomenon is explained by the activation of complementary signaling pathways that mutually potentiate each other (Bowers et al., Endocrine 1998)
Bottom line: Its important to talk to your doctor about whether these drugs are right for you
Primary care physicians will likely need education and training focused on this new class of medications, given a shortage of endocrinologists and obesity medicine specialists. Lee and colleagues noted there were study limitations, such as a lack of data on prescription indication, including whether it was used off-label. However, the increase in dispensing of injectable semaglutide for weight management suggests increasing use for this indication, they wrote
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